4-AcO-DMT Psilacetin — Trusted 99% Purity 2025

4-AcO-DMT psilacetin — formally known as O-Acetylpsilocin or 4-acetoxy-DMT — is a semi-synthetic psychoactive compound belonging to the substituted tryptamine class. First synthesized in 1963 by Albert Hofmann and Franz Troxler at Sandoz Ltd., this compound has attracted growing interest in the research community as a structurally elegant relative of psilocybin. Available here in powder form at ≥99.0% purity, it comes in multiple quantities to suit your research needs.

What Is 4-AcO-DMT Psilacetin?
Key Benefits of Researching with 4-AcO-DMT Psilacetin
Who Is This For?
Features at a Glance
Comparing 4-AcO-DMT to Related Tryptamines
Specifications
How to Choose the Right Quantity of 4-AcO-DMT Psilacetin for Your Research

4-AcO-DMT psilacetin powder in a clear research vial showing white crystalline solid at ≥99% purity

What Is 4-AcO-DMT Psilacetin?

4-AcO-DMT is the acetylated form of psilocin, sharing a molecular backbone with both psilocybin and psilocin. Its molecular formula is C14H18N2O2, with an average mass of 246.3049 g·mol⁻¹ and a CAS number of 92292-84-7. Pharmacologist David E. Nichols highlighted its potential in a landmark 1999 paper, suggesting it as a practical alternative to psilocybin in controlled pharmacological research settings.

Because it is believed to act as a prodrug of psilocin — converting during first-pass metabolism — its subjective and pharmacological profile is considered closely related to psilocybin mushroom alkaloids. It acts primarily by stimulating serotonin receptors in the brain, placing it firmly within the classical psychedelic category.

Despite its 1963 origins, meaningful research into its properties only gained momentum in the 2010s when it appeared on the research chemical market. Today it remains one of the most discussed tryptamine compounds in psychedelic science circles.

Key Benefits of Researching with 4-AcO-DMT Psilacetin

High chemical purity: Each batch is tested to ≥99.0% purity, giving researchers a consistent and reliable starting point.
Well-documented chemistry: A known CAS number, molecular formula, and synthesis history make literature cross-referencing straightforward.
Flexible quantities: Available in 2 g, 5 g, 10 g, ½ oz, and 1 oz options to match small pilot studies or larger research programs.
Structural clarity: Its relationship to psilocin and psilocybin is well-mapped, making it easier to contextualize findings within existing literature.
Stable shelf life: Rated stable for up to 2 years when stored correctly at -20°C.
Reported tolerability profile: User reports in the research community frequently note a comparatively manageable body-load profile relative to psilocin.

Who Is This For?

This compound is intended for researchers, chemists, and pharmacology professionals who are exploring the tryptamine class of compounds. It is particularly relevant for those studying serotonergic mechanisms, prodrug metabolism pathways, or comparative psychedelic pharmacology.

It is also of interest to institutions comparing the effects and metabolic profiles of structurally similar indole alkaloids. If your work involves understanding how acetylated tryptamines behave relative to their parent compounds, 4-AcO-DMT is a logical compound to include in your study design.

This is not a recreational product. It is sold strictly for legitimate research purposes in jurisdictions where such research is permitted.

Features at a Glance

Feature	Detail
Compound Class	Substituted tryptamine
Also Known As	O-Acetylpsilocin, psilacetin, 4-acetoxy-DMT
Physical Form	Powder solid
Purity	≥99.0%
Available Quantities	2 g, 5 g, 10 g, ½ oz, 1 oz
Storage Requirement	-20°C
Shelf Stability	2 years
Shipping (US)	Wet ice in the continental US

Researchers often consider 4-AcO-DMT alongside its structural relatives. It is a lower homolog of 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT — all of which share the core 4-acetoxy-tryptamine scaffold but differ in their N-substitution patterns. This makes 4-AcO-DMT a useful reference compound when building a comparative study across the 4-AcO series.

Its relationship to psilocybin is particularly notable. Both compounds are believed to serve as prodrugs for psilocin, yet their metabolic pathways and onset kinetics may differ. Some user reports suggest a slightly different duration and visual character compared to psilocin alone, though no controlled clinical trials have formally quantified these differences.

Understanding these nuances is exactly the kind of question that well-designed pharmacological research can begin to answer — and having a high-purity sample of O-Acetylpsilocin is the first step.

Specifications

Specification	Value
Product Name	4-AcO-DMT (Psilacetin)
Full Chemical Name	3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl acetate
Formal Name	Psilocin, 4-acetoxy-DMT, O-Acetylpsilocin
CAS Number	92292-84-7
Molecular Formula	C14H18N2O2
Average Mass	246.3049 g·mol⁻¹
Purity	≥99.0%
Stability	2 years
Storage	-20°C
Formulation	Powder solid
λmax	221, 315 nm
Shipping	Wet ice in the continental US; may vary elsewhere

How to Choose the Right Quantity of 4-AcO-DMT Psilacetin for Your Research

Picking the right quantity before you order saves you time, money, and the hassle of running short mid-experiment. Here’s a friendly, practical breakdown to help you decide what makes sense for your situation.

If you’re just getting started with tryptamine research or running a small pilot study, the 2-gram option is a smart entry point. It gives you enough material to establish your analytical baseline, run preliminary assays, and verify your storage setup — without committing to a larger volume before you know exactly what your workflow requires.

For researchers with an established protocol who need a comfortable working supply, the 5-gram or 10-gram options hit a practical sweet spot. They provide enough material for multiple experimental runs while keeping costs manageable. These mid-range sizes are also popular for comparative studies where 4-AcO-DMT psilacetin is being evaluated alongside related tryptamine compounds.

If you’re running a longer-term study, supplying a research group, or simply prefer to minimize reorder frequency, the ½-ounce or full-ounce quantities offer the best value per gram. Given the compound’s 2-year stability at -20°C, buying in a larger quantity is a practical choice as long as your cold storage is reliable.

A few things to keep in mind before you order:

Cold storage readiness: Make sure your -20°C freezer space is available before your order arrives, especially for larger quantities.
Jurisdictional compliance: Confirm that purchasing and possessing this compound is permitted in your jurisdiction before placing an order.
Intended use documentation: Keep clear records of your research purpose — this is standard practice when working with novel research chemicals.
Shipping timing: Because orders ship on wet ice, plan your delivery for a day when someone can receive and refrigerate the package promptly.
Spectroscopic verification: Upon receipt, UV spectroscopy at 221 and 315 nm is a quick way to confirm compound identity and purity.

When in doubt, start with a smaller quantity and scale up once your methodology is dialed in. The purity and consistency you get here means your data will be just as solid whether you’re working with 2 grams or a full ounce.

Frequently Asked Questions

What is 4-AcO-DMT psilacetin used for?

4-AcO-DMT (psilacetin) is primarily used as a research compound in pharmacological and neurochemical studies. It is of particular interest to researchers studying serotonergic psychedelics and prodrug metabolism. David E. Nichols suggested it as a practical alternative to psilocybin in controlled research settings. It is not intended for human consumption.

How does 4-AcO-DMT compare to psilocybin?

Both 4-AcO-DMT and psilocybin are believed to act as prodrugs of psilocin, meaning they are thought to convert to psilocin in the body. Their molecular structures are closely related, and their pharmacological profiles are considered broadly similar. However, no controlled clinical studies have formally quantified the differences between the two compounds.

What purity level does this 4-AcO-DMT come in?

This product is offered at ≥99.0% purity, making it suitable for precise research applications. The high purity level ensures that measurements and experimental results are not significantly skewed by impurities. Researchers can verify purity using UV spectroscopy at the compound's λmax of 221 and 315 nm.

How should I store 4-AcO-DMT powder?

4-AcO-DMT should be stored at -20°C to maintain its stability and purity over time. Under these conditions, the compound has a rated shelf life of 2 years. Avoid exposure to moisture, light, and temperature fluctuations, as these can degrade the compound more quickly.

What quantity options are available for purchase?

This product is available in 2 grams, 5 grams, 10 grams, ½ ounce, and 1 ounce quantities. This range accommodates both small-scale exploratory research and larger, ongoing study programs. Pricing starts at $150 — contact us for bulk research inquiries.

Who first synthesized O-Acetylpsilocin?

O-Acetylpsilocin was first synthesized by Albert Hofmann and Franz Troxler at Sandoz Ltd., with the synthesis first reported in 1963. The compound was patented alongside several other psilocin esters but was not studied extensively at the time. Its research profile gained more attention following a 1999 paper by David E. Nichols.

Is 4-AcO-DMT the same as DMT?

No — 4-AcO-DMT and DMT (N,N-dimethyltryptamine) are distinct compounds, though both belong to the tryptamine class. 4-AcO-DMT is the 4-acetoxy analog of psilocin and is structurally more similar to psilocybin than to DMT. The '4-AcO' prefix indicates the acetoxy group at the 4-position of the indole ring, which is absent in DMT.

How is 4-AcO-DMT shipped from Florida Gas Packs?

Orders within the continental United States are shipped on wet ice to preserve the compound's integrity during transit. Shipping conditions may vary for orders outside the continental US. We recommend having appropriate cold storage ready upon delivery to maintain the sample's quality.

Learn more about psilocybin pharmacology research.

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